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Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis by Aiqin Li; Ifrah Nabi Khan; Ikram Ullah Khan; Abid Mehmood Yousaf; Yasser Shahzad is a Medicine article available to read on EtoBox.

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## Background/Objective Periodontitis is a widely spread oral infection and various antibiotics are utilized for its treatment, but high oral doses and development of antibiotic resistance limit their use. This study was aimed at development of natural polymer-based mucoadhesive bilayer films loaded with moxifloxacin hydrochloride (Mox) and clove essential oil (CEO) to potentially combat bacterial infection associated with periodontitis. ## Methods Films were synthesized by double solvent casting technique having an antibiotic in the gellan gum-based primary layer with clove oil in a hydroxyethyl cellulose-based secondary layer. ## Results Prepared films were transparent, flexible, and showed high antibacterial response against both gram-positive and gram-negative bacteria. The films showed excellent pharmaceutical attributes in terms of drug content, folding endurance, swelling index, and mucoadhesive strength. Solid state characterization of formulation showed successful incorporation of drug and oil in separate layers of hydrogel structure. An in-vitro release study showed an initial burst release of drug followed by sustained release for up to 48 hours. ## Conclusion The prepar

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Author

Aiqin Li; Ifrah Nabi Khan; Ikram Ullah Khan; Abid Mehmood Yousaf; Yasser Shahzad

Published

2021

Language

EN

Field

Medicine (Health Sciences)