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Adolescent Sleep and the Foundations of Prefrontal Cortical Development and Dysfunction by Paul G. Anastasiades; Luisa de Vivo; Michele Bellesi; Matt W. Jones is a Neuroscience article available to read on EtoBox.

What is Adolescent Sleep and the Foundations of Prefrontal Cortical Development and Dysfunction about?

Modern life poses many threats to good-quality sleep, challenging brain health across the lifespan. Curtailed or fragmented sleep may be particularly damaging during adolescence, when sleep disruption by delayed chronotypes and societal pressures coincides with our brains preparing for adult life via intense refinement of neural connectivity. These vulnerabilities converge on the prefrontal cortex, one of the last brain regions to mature and a central hub of the limbic-cortical circuits underpinning decision-making, reward processing, social interactions and emotion. Even subtle disruption of prefrontal cortical development during adolescence may therefore have enduring impact. In this review, we integrate synaptic and circuit mechanisms, glial biology, sleep neurophysiology and epidemiology, to frame a hypothesis highlighting the implications of adolescent sleep disruption for the neural circuitry of the prefrontal cortex. Convergent evidence underscores the importance of acknowledging, quantifying and optimizing adolescent sleep’s contributions to normative brain development and to lifelong mental health.

Who reads Adolescent Sleep and the Foundations of Prefrontal Cortical Development and Dysfunction?

Author

Paul G. Anastasiades; Luisa de Vivo; Michele Bellesi; Matt W. Jones

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Neuroscience (Life Sciences)