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Pressure‐independent Enhancement of Cardiac Hypertrophy in Atrial Natriuretic Peptide–deficient Mice by Ji An Feng; Gilbert Perry; Tatsuhiko Mori; Tetsuya Hayashi; Suzanne Oparil; Yiu‐Fai Chen is a Medicine article available to read on EtoBox.

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## Summary 1. Homozygous deletion of the pro‐atrial natriuretic peptide (__Nppa__) gene (ANP–/–) has been associated with both cardiac hypertrophy and salt‐sensitive hypertension in mice, suggesting that cardiac hypertrophy in ANP–/– mice may be related, at least in part, to increased afterload. 2. To test the hypothesis that cardiac hypertrophy in ANP–/– mice is independent of blood pressure, male ANP–/– and wild‐type ANP+/+ mice were fed a low (0.05%) or basal (0.55%) NaCl diet. Five weeks later, mean arterial pressure (MAP) was measured in conscious mice; the whole heart, atria, left and right ventricles (LV and RV, respectively), brain, lung, kidney, liver and spleen were weighed and fixed for histological analysis. Separate groups of mice were subjected to echocardiographic examination under tribromoethanol anaesthesia. 3. Mean arterial pressure and atrial, LV and RV mass were greater in ANP–/– mice than in ANP+/+ mice fed the basal salt diet. Salt depletion equalized MAP in the two genotypes, but did not alter the relative cardiac hypertrophy in ANP–/– mice. The ANP–/– mice had significant LV cardiomyocyte hypertrophy when fed either basal or low‐salt diets. 4. Left ventricle

Who reads Pressure‐independent Enhancement of Cardiac Hypertrophy in Atrial Natriuretic Peptide–deficient Mice?

Author

Ji An Feng; Gilbert Perry; Tatsuhiko Mori; Tetsuya Hayashi; Suzanne Oparil; Yiu‐Fai Chen

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0305-1870)

Published

2003

Language

EN

Field

Medicine (Health Sciences)