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Blood Pressure and the Risk of Rebleeding and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage by Celine S. Gathier; IJsbrand A.J. Zijlstra; Gabriel J.E. Rinkel; T. Katrien J. Groenhof; Dagmar Verbaan; Bert A. Coert; Marcella C.A. Müller; Walter M. van den Bergh; Arjen J.C. Slooter; Marinus J.C. Eijkemans is a Medicine article available to read on EtoBox.

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## Introduction and objective: Blood pressure is presumably related to rebleeding and delayed cerebral ischemia (dci) after subarachnoid hemorrhage (asah) and could serve as a target to improve outcome. we assessed the associations between blood pressure and rebleeding or dci in asah-patients. ## Materials and methods: In this observational study in 1167 asah-patients admitted to the intensive care unit (icu), adjusted hazard ratio's (ahr) were calculated for the time-dependent association of blood pressure and rebleeding or dci. the ahrs were presented graphically, relative to a reference mean arterial pressure (map) of 100 mmhg and systolic blood pressure (sbp) of 150 mmhg. ## Results: A map below 100 mmhg in the 6, 3 and 1 h before each moment in time was associated with a decreased risk of rebleeding (e.g. within 6 h preceding rebleeding: map = 80 mmhg: ahr 0.30 (95% confidence interval (ci) 0.11-0.80)). a map below 60 mmhg in the 24 h before each moment in time was associated with an increased risk of dci (e.g. map = 50 mmhg: ahr 2.59 (95% ci 1.12-5.96)). ## Conclusions: Our results suggest that a map below 100 mmhg is associated with decreased risk of rebleeding, and a map be

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Author

Celine S. Gathier; IJsbrand A.J. Zijlstra; Gabriel J.E. Rinkel; T. Katrien J. Groenhof; Dagmar Verbaan; Bert A. Coert; Marcella C.A. Müller; Walter M. van den Bergh; Arjen J.C. Slooter; Marinus J.C. Eijkemans

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)