Opening book details…
Can I read Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression on EtoBox?
Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression by Xu, Jianfeng (author);Shi, Jiejun (author);Cui, Xiaodong (author);Cui, Ya (author);Li, Jingyi Jessica (author);Goel, Ajay (author);Chen, Xi (author);Issa, Jean-Pierre (author);Su, Jianzhong (author);Li, Wei (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression about?
## Abstract Promoter DNA methylation is a well-established mechanism of transcription repression, though its global correlation with gene expression is weak. This weak correlation can be attributed to the failure of current methylation quantification methods to consider the heterogeneity among sequenced bulk cells. Here, we introduce Cell Heterogeneity–Adjusted cLonal Methylation (CHALM) as a methylation quantification method. CHALM improves understanding of the functional consequences of DNA methylation, including its correlations with gene expression and H3K4me3. When applied to different methylation datasets, the CHALM method enables detection of differentially methylated genes that exhibit distinct biological functions supporting underlying mechanisms.
Who reads Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Xu, Jianfeng (author);Shi, Jiejun (author);Cui, Xiaodong (author);Cui, Ya (author);Li, Jingyi Jessica (author);Goel, Ajay (author);Chen, Xi (author);Issa, Jean-Pierre (author);Su, Jianzhong (author);Li, Wei (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)