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Oral Microbial Community Analysis of the Patients in the Progression of Liver Cancer by Daxu Li; Weijun Xi; Zhe Zhang; Le Ren; Chunni Deng; Jianghao Chen; Cong Sun; Nan Zhang; Jiru Xu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Oral Microbial Community Analysis of the Patients in the Progression of Liver Cancer about?

Liver disease has been reported to associate with oral microbiota. This study aimed to identify the salivary microbial structure in liver disease patients and determine whether the disease progression influence the bacterial composition. 16S rDNA high-throughput sequencing and bioinformatic analysis were used to examine oral bacterial diversity in the different status of hepatitis patients including 6 patients with Hepatitis B (Y), 6 patients with Hepatitis B Cirrhosis (YY) and 6 patients with liver cancer (C), and 6 healthy controls (T). Phylogenetic analysis revealed that the genera of Streptococcus, Prevotella, Actinomyces, Veillonella and Neisseria are predominant genus in the saliva of Y, YY, C patients and T group. Lautropia, Abiotrophia and Veillonella were enriched in Y patients, while Treponema, Selenomonas and Oribacterium were also existed in YY patients. Haemophilus, Porphyromonas and Filifactor had high abundance in C patients. The genera of Moryella, Leptotrichia, Lactobacillus, Dialister, Serratia, Enterococcus and Actinobacillus were decreased in all patient samples compared with healthy control samples which may be used for treatment of liver disease. Diversity ana

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Author

Daxu Li; Weijun Xi; Zhe Zhang; Le Ren; Chunni Deng; Jianghao Chen; Cong Sun; Nan Zhang; Jiru Xu

Publisher

Elsevier BV

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)