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Interleukins, growth factors, and transcription factors are key targets for gene therapy in osteoarthritis: A scoping review by Melanie Uebelhoer; Cécile Lambert; Juliane Grisart; Kilian Guse; Stanislav Plutizki; Yves Henrotin is a Medicine article available to read on EtoBox.
What is Interleukins, growth factors, and transcription factors are key targets for gene therapy in osteoarthritis: A scoping review about?
## Objective Osteoarthritis (OA) is the most common degenerative joint disease, characterized by a progressive loss of cartilage associated with synovitis and subchondral bone remodeling. There is however no treatment to cure or delay the progression of OA. The objective of this manuscript was to provide a scoping review of the preclinical and clinical studies reporting the effect of gene therapies for OA. ## Method This review followed the JBI methodology and was reported in accordance with the PRISMA-ScR checklist. All research studies that explore __in vitro, in vivo__, or __ex vivo__ gene therapies that follow a viral or non-viral gene therapy approach were considered. Only studies published in English were included in this review. There were no limitations to their date of publication, country of origin, or setting. Relevant publications were searched in Medline ALL (Ovid), Embase (Elsevier), and Scopus (Elsevier) in March 2023. Study selection and data charting were performed by two independent reviewers. ## Results We found a total of 29 different targets for OA gene therapy, including studies examining interleukins, growth factors and receptors, transcription factors and ot
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- Author
- Melanie Uebelhoer; Cécile Lambert; Juliane Grisart; Kilian Guse; Stanislav Plutizki; Yves Henrotin
- Publisher
- Frontiers Media SA
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)