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Can I read LC-MS and NMR determination of a dichloromethane artifact adduct, cyproheptadine chloromethochloride on EtoBox?
LC-MS and NMR determination of a dichloromethane artifact adduct, cyproheptadine chloromethochloride by Min Li; Eric S Ahuja; Diana M Watkins is a Chemistry article available to read on EtoBox.
What is LC-MS and NMR determination of a dichloromethane artifact adduct, cyproheptadine chloromethochloride about?
The British Pharmacopoeia (BP) monograph for cyproheptadine HCl tablets requires a 'Related substances' thin-layer chromatography (TLC) test. This test revealed an extraneous spot with an R(f) of 0.1 in certain cyproheptadine HCl tablets that were under ambient retention conditions as well as those on stability programs. An investigation utilizing LC-MS, direct infusion MS, NMR, and organic synthesis has identified that the spot results from the N-oxide of cyproheptadine (a genuine degradate) and a co-eluting cyproheptadine-dichloromethane adduct, an artifact formed during the sample extraction step in which dichloromethane is used in the extracting solvent.
Who reads LC-MS and NMR determination of a dichloromethane artifact adduct, cyproheptadine chloromethochloride?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Min Li; Eric S Ahuja; Diana M Watkins
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)
- Published
- 2003
- Language
- EN
- Field
- Chemistry (Physical Sciences)