About this Neuroscience article
Blocking the Dopaminergic Receptors in the Hippocampal Dentate Gyrus Reduced the Stress-induced Analgesia in Persistent Inflammatory Pain in the Rat by Pooriya Ghanbari Merdasi; Ramin Abdi Dezfouli; Sajad Mazaheri; Abbas Haghparast is a Neuroscience article available to read on EtoBox.
Although the dentate gyrus (DG) as a component of the hippocampal formation has been well known for its role in memory, various studies showed a diverse population of unique cell types and various inputs and outputs in this region. Besides, brain dopamine is known for its roles in reward, motivation, pleasure, and being involved in the pain process. Further, previous studies demonstrated the participation of DG dopaminergic receptors in antinociception induced by lateral hypothalamus stimulation. This study aimed to investigate the role of DG dopaminergic receptors (D1- and D2-like dopamine receptors) in stress-induced analgesia (SIA) using the formalin test as a persistent inflammatory pain model. One hundred two male Wistar rats were unilaterally implanted with a cannula into the DG. Animals received an intra-DG infusion of SCH23390 (0.25, 1, and 4 μg/rat), or Sulpiride (0.25, 1, and 4 μg/rat) as D1- and D2-like dopamine receptor antagonists, respectively, five min before exposure to forced swim stress (FSS). Ten minutes after FSS termination, 2.5% formalin solution as an inflammatory agent was subcutaneously injected into the plantar surface of the hind paw, and the pain score w
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- Author
- Pooriya Ghanbari Merdasi; Ramin Abdi Dezfouli; Sajad Mazaheri; Abbas Haghparast
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Neuroscience (Life Sciences)