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The study identifies thrombopoietin (ML) as the ligand for the Mpl receptor, which plays a crucial role in the proliferation of primitive hematopoietic progenitors in mice. ML was shown to synergize with steel factor (SF) and other early acting cytokines to enhance colony formation from multipotential progenitors, particularly in serum-containing cultures. The findings suggest that ML can stimulate the proliferation of dormant progenitors by triggering their cell cycle, indicating its potential role as an e

Author

wang2022pharm

Language

EN