Opening book details…
Can I read Do diurnal salivary cortisol curves carry meaningful information about the regulatory biology of the HPA axis in healthy humans? on EtoBox?
Do diurnal salivary cortisol curves carry meaningful information about the regulatory biology of the HPA axis in healthy humans? by James L. Abelson; Brisa N. Sánchez; Stefanie E. Mayer; Hedieh Briggs; Israel Liberzon; Nirmala Rajaram is a Neuroscience article available to read on EtoBox.
What is Do diurnal salivary cortisol curves carry meaningful information about the regulatory biology of the HPA axis in healthy humans? about?
Salivary cortisol stress biomarkers have been extensively used in epidemiological work to document links between stress and ill health. There has been little effort to ground field friendly cortisol measures in the hypothalamic-pituitary-adrenal (HPA) axis regulatory biology that is likely relevant to delineating mechanistic pathways leading from stress exposure to detrimental health outcomes. Here, we utilized a healthy convenience sample (n = 140) to examine normal linkages between extensively collected salivary cortisol measures and available laboratory probes of HPA axis regulatory biology. Participants provided 9 saliva samples per day over 6 days within a month, while engaging in usual activities, and also participated in 5 regulatory tests (adrenocorticoptripin stimulation, dexamethasone/corticotropin-releasing-hormone stimulation, metyrapone, dexamethasone suppression, and Trier Social Stress Test). Logistical regression was used to test specific predictions linking cortisol curve components to regulatory variables and to explore widely for non-predicted associations. We found support for 2 of 3 original hypotheses, showing associations (1) between cortisol diurnal decline
Who reads Do diurnal salivary cortisol curves carry meaningful information about the regulatory biology of the HPA axis in healthy humans??
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- James L. Abelson; Brisa N. Sánchez; Stefanie E. Mayer; Hedieh Briggs; Israel Liberzon; Nirmala Rajaram
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Neuroscience (Life Sciences)