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Improved Outcomes Associated with Maximal Extent of Resection for Butterfly Glioblastoma: Insights from Institutional and National Data by Alessandro Boaro; Vasileios K. Kavouridis; Francesca Siddi; Elisabetta Mezzalira; Maya Harary; J. Bryan Iorgulescu; David A. Reardon; Timothy R. Smith is a Medicine article available to read on EtoBox.
What is Improved Outcomes Associated with Maximal Extent of Resection for Butterfly Glioblastoma: Insights from Institutional and National Data about?
Background Butterfly glioblastomas (bGBMs) are grade IV gliomas that infiltrate the corpus callosum and spread to bilateral cerebral hemispheres. Due to the rarity of cases, there is a dearth of information in existing literature. Herein, we evaluate clinical and genetic characteristics, associated predictors, and survival outcomes in an institutional series and compare them to a national cohort. Methods We identified all adult patients with bGBM treated at Brigham & Women's Hospital (2008-2018). The National Cancer Database (NCDB) was also queried for bGBM patients. Survival was analyzed with Kaplan-Meier methods, and Cox models were built to assess for predictive factors. Results Of 993 glioblastoma patients, 62 cases (6.2%) of bGBM were identified. Craniotomy for resection was attempted in 26 patients (41.9%), with a median volumetric extent of resection (vEOR) of 72.3% (95% confidence interval [95%CI] 58.3-82.1). The IDH1 R132H mutation was detected in two patients (3.2%), and MGMT promoter was methylated in 55.5% of the assessed cases. In multivariable regression, factors predictive of longer OS were increased vEOR, MGMT promoter methylation, and receipt of adjuvant therapy. M
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- Author
- Alessandro Boaro; Vasileios K. Kavouridis; Francesca Siddi; Elisabetta Mezzalira; Maya Harary; J. Bryan Iorgulescu; David A. Reardon; Timothy R. Smith
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)