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Can I read Regulation of KLF4 by posttranslational modification circuitry in endocrine resistance on EtoBox?
Regulation of KLF4 by posttranslational modification circuitry in endocrine resistance by Zhuan Zhou; Xinxin Song; Junlong (Jack) Chi; David R. Gius; Yi Huang; Massimo Cristofanilli; Yong Wan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Regulation of KLF4 by posttranslational modification circuitry in endocrine resistance about?
KLF4 plays an important role in orchestrating a variety of cellular events, including cell-fate decision, genome stability and apoptosis. Its deregulation is correlated with human diseases such as breast cancer and gastrointestinal cancer. Results from recent biochemical studies have revealed that KLF4 is tightly regulated by posttranslational modifications. Here we report a new finding that KLF4 orchestrates estrogen receptor signaling and facilitates endocrine resistance. We also uncovered the underlying mechanism that alteration of KLF4 by posttranslational modifications such as phosphorylation and ubiquitylation changes tumor cell response to endocrine therapy drugs. IHC analyses using based on human breast cancer specimens showed the accumulation of KLF4 protein in ER-positive breast cancer tissues. Elevated KLF4 expression significantly correlated with prognosis and endocrine resistance. Our drug screening for suppressing KLF4 protein expression led to identification of Src kinase to be a critical player in modulating KLF4-mediated tamoxifen resistance. Depletion of VHL (von Hippel-Lindau tumor suppressor), a ubiquitin E3 ligase for KLF4, reduces tumor cell sensitivity to tam
Who reads Regulation of KLF4 by posttranslational modification circuitry in endocrine resistance?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Zhuan Zhou; Xinxin Song; Junlong (Jack) Chi; David R. Gius; Yi Huang; Massimo Cristofanilli; Yong Wan
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0898-6568)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)