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What is Portugal Et Al 2017 about?

The study investigates the role of the vitamin C transporter SVCT2 in microglia, revealing that its internalization, mediated by caveolin-1, triggers a proinflammatory phenotype. Depletion of SVCT2 leads to microglial activation and increased production of inflammatory markers, indicating its critical role in maintaining microglial homeostasis. Dysregulation of ascorbate transport through SVCT2 may contribute to neurological disorders, highlighting its potential as a therapeutic target.

Author

Carolina Enxuga Sá Martins

Language

EN