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fMRI correlates of interictal epileptic activity in patients with idiopathic benign focal epilepsy of childhood: A simultaneous EEG–functional MRI study by Ulrike Lengler; Ihsan Kafadar; Bernd A. Neubauer; Karsten Krakow is a Medicine article available to read on EtoBox.

What is fMRI correlates of interictal epileptic activity in patients with idiopathic benign focal epilepsy of childhood: A simultaneous EEG–functional MRI study about?

EEG-correlated fMRI (EEG/fMRI) can identify alterations of brain function associated with interictal epileptiform discharges (IED). fMRI activation can localize the irritative zone and indicate functional disturbance distant from the spike focus. This might be of particular interest in paediatric epilepsy syndromes with frequent IED. Using simultaneous EEG/fMRI in a 3 T MR scanner we studied blood oxygen level-dependent (BOLD) signal changes related to spontaneous IED in 10 children with typical and atypical benign focal epilepsy of childhood (BFE) or benign epileptic activity of childhood (BEAC). EEG artefacts were subtracted offline and IED were used as regressors for event-related fMRI analysis in SPM2. In four of the seven children with IED during EEG/fMRI we found IED related positive and negative signal changes (p < 0.001, uncorrected). In three children we found only significant negative signal changes. At a more liberal threshold (p < 0.05, uncorrected) these three children had positive signal changes congruent with the four children with significant positive signal changes. In summary, we found positive or negative signal changes in perisylvian, central, premotor and prefr

Who reads fMRI correlates of interictal epileptic activity in patients with idiopathic benign focal epilepsy of childhood: A simultaneous EEG–functional MRI study?

Author

Ulrike Lengler; Ihsan Kafadar; Bernd A. Neubauer; Karsten Krakow

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)

Published

2007

Language

EN

Field

Medicine (Health Sciences)