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Comparison of CD34+ cell collection efficiency on the COBE Spectra and Fenwal CS‐3000 plus by C.D. Ford; C. Lehman; A. Strupp; L. Kelley is a Medicine article available to read on EtoBox.

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## Abstract Optimal collections of mobilized CD34+ cells are important in terms of both patient toxicity and cost. The factors that determine CD34+ collection efficiency (CD34eff) of cell separators have not been well studied. In addition, because several cell separators are available, the type of collection device may also be a significant variable. Previous studies comparing the Baxter‐Fenwal CS3000 and the COBE Spectra have not yielded consistent conclusions. Therefore, we retrospectively analyzed the collection outcomes of 163 consecutive donors with a peripheral CD34+ cell concentration (pCD34) of ≥5 cells/μl on the first collection that had been harvested on one or the other device. The CS3000 was found to yield a significantly higher CD34eff (50% vs. 39%, __P__ = 0.006). However, donors were not balanced for several prognostic factors, which may contribute to CD34eff including mobilization with G‐CSF vs. chemotherapy+G‐CSF, average flow rate, and total volume of peripheral blood processed. When appropriate variables were included in a stepwise multiple variable analysis, cell separator type emerged as a significant independent predictive factor for CD34eff (__P__ = 0.018). O

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Author

C.D. Ford; C. Lehman; A. Strupp; L. Kelley

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0733-2459)

Published

2002

Language

EN

Field

Medicine (Health Sciences)