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Western influenced lifestyle and Kv2.1 association as predicted biomarkers for Tunisian colorectal cancer by Barbirou, Mouadh; Woldu, Henok G.; Sghaier, Ikram; Bedoui, Sinda A.; Mokrani, Amina; Aami, Radhia; Mezlini, Amel; Yacoubi-Loueslati, Besma; Tonellato, Peter J.; Bouhaouala-Zahar, Balkiss is a Medicine article available to read on EtoBox.
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## Abstract ## Background Colorectal cancer (CRC) is the third most diagnosed malignancy worldwide. The global burden is expected to increase along with ongoing westernized behaviors and lifestyle. The etiology of CRC remains elusive and most likely combines environmental and genetic factors. The Kv2.1 potassium channel encoded by KCNB1 plays a collection of roles in malignancy of cancer and may be a key factor of CRC susceptibility. Our study provides baseline association between Tunisian CRC and interactions between KCNB1 variants and lifestyle factors. ## Methods A case-control study involving 300 CRC patients, and 300 controls was conducted Patients were carefully phenotyped and followed till the end of study. KCNB1 genotyping was confirmed by Sanger sequencing. Bivariate and multivariable logistic regression analyses were used to assess the clinical status, lifestyle and study polymorphisms association with CRC. ## Results We noted significant gender association with CRC occurrence. Moreover, CRC risk increases with high meat and fat consumption, alcohol use and physical activity (PA). Carriage of rs1051296 A/G and both rs11468831 ins/del and del/del genotypes (p < 0.001) were
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- Author
- Barbirou, Mouadh; Woldu, Henok G.; Sghaier, Ikram; Bedoui, Sinda A.; Mokrani, Amina; Aami, Radhia; Mezlini, Amel; Yacoubi-Loueslati, Besma; Tonellato, Peter J.; Bouhaouala-Zahar, Balkiss
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2001]-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2407)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)