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Stochastic Dynamics of the Nerve Growth Cone and Its Microtubules During Neurite Outgrowth by David J. Odde; Elly M. Tanaka; Stacy S. Hawkins; Helen M. Buettner is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Stochastic Dynamics of the Nerve Growth Cone and Its Microtubules During Neurite Outgrowth about?

The controlled extension of neurites is essential not only for nervous system development, but also for effective nerve regeneration after injury. This process is critically dependent on microtubule assembly since axons fail to elongate in the presence of drugs which disrupt normal assembly dynamics. For this reason, neurite outgrowth is potentially controllable by manipulation of the assembly state of the intracellular array of microtubules. Therefore, understanding how microtubule assembly dynamics and neurite outgrowth are coupled, in the absence of drugs, can lend valuable insight into the control and guidance of the outgrowth process. In the present study we characterized the stochastic dynamics of neurite outgrowth and its corresponding microtubule array, which advances concomitantlywith the advance ofthe nerve growth cone, the highly motile structure at the terminus of the growing neurite, using reported fluorescent microscopic image sequences (Tanaka and Kirschner, 1991, J. Cell Biol. 115:345-363). Although previously modeled as an uncorrelated random walk, the stochastic advance of the growth cone was found to be anticorrelated over a time scale of -4 min, meaning that gro

Who reads Stochastic Dynamics of the Nerve Growth Cone and Its Microtubules During Neurite Outgrowth?

Author

David J. Odde; Elly M. Tanaka; Stacy S. Hawkins; Helen M. Buettner

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley - V C H Verlag GmbbH & Co.; Wiley (ISSN 0006-3592)

Published

2000

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)