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On the Relationship between Genomic Regulatory Element Organization and Gene Regulatory Dynamics by Denise M Wolf; Frank H. Eeckman is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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In this project we study the relationship between genomic regulatory element organization and gene regulatory dynamics. This paper illustrates an approach to investigating this relationship based on the application of classical nonlinear system analysis techniques to a transcription level, statistical thermodynamical model like that used in Shea & Ackers (1985). Preliminary ideas presented at the ICMCM conference (Wolf & Eeckman, 1998) are developed in this manuscript. We show that, for prokaryotic gene circuits dominated by local promoter control, dynamical system behavior descriptors like the number and stability of equilibrium point steady states and their bifurcation potential can be largely determined from genomic organization (e.g. the number, type, and placement of regulatory protein binding sites). Concepts are illustrated on hypothetical gene regulation systems with one or two genes and varying numbers of regulatory protein binding sites (operators). Gene regulatory systems with a single gene and an arbitrary number of operator sites are shown to be globally stable, with the potential for having multiple equilibrium points and capable of bifurcating. A monomer-controlled g

Who reads On the Relationship between Genomic Regulatory Element Organization and Gene Regulatory Dynamics?

Author

Denise M Wolf; Frank H. Eeckman

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-5193)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)