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The JigCell Model Builder: A Spreadsheet Interface for Creating Biochemical Reaction Network Models by M.T. Vass; C.A. Shaffer; N. Ramakrishnan; L.T. Watson; J.J. Tyson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The JigCell Model Builder: A Spreadsheet Interface for Creating Biochemical Reaction Network Models about?

Converting a biochemical reaction network to a set of kinetic rate equations is tedious and error prone. We describe known interface paradigms for inputing models of intracellular regulatory networks: graphical layout (diagrams), wizards, scripting languages, and direct entry of chemical equations. We present the JigCell Model Builder, which allows users to define models as a set of reaction equations using a spreadsheet (an example of direct entry of equations) and outputs model definitions in the Systems Biology Markup Language, Level 2. We present the results of two usability studies. The spreadsheet paradigm demonstrated its effectiveness in reducing the number of errors made by modelers when compared to hand conversion of a wiring diagram to differential equations. A comparison of representatives of the four interface paradigms for a simple model of the cell cycle was conducted which measured time, mouse clicks, and keystrokes to enter the model, and the number of screens needed to view the contents of the model. All four paradigms had similar data entry times. The spreadsheet and scripting language approaches require significantly fewer screens to view the models than do the

Who reads The JigCell Model Builder: A Spreadsheet Interface for Creating Biochemical Reaction Network Models?

Author

M.T. Vass; C.A. Shaffer; N. Ramakrishnan; L.T. Watson; J.J. Tyson

Publisher

Institute of Electrical and Electronics Engineers (IEEE)

Published

2006

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)