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Association of KLOTHO gene polymorphisms with knee osteoarthritis in Greek population by Aspasia Tsezou; Tatsuya Furuichi; Maria Satra; Periklis Makrythanasis; Shiro Ikegawa; Konstantinos N. Malizos is a Medicine article available to read on EtoBox.

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## Abstract Based on the fact that klotho‐deficient mice exhibit multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints and on the recent observation that __KLOTHO__ gene plays an important role in calcium/phosphate homeostasis, we explored the possibility whether human __KLOTHO__ gene polymorphisms are associated with osteoarthritis (OA). A total of 752 individuals participated in the study. The knee OA group consisted of 369 patients; 298 women (mean age 65.9 ± 8.2; range 40–92 years) and 71 men (mean age 65.7 ± 9.1; range 30–82 years). The control population consisted of 383 subjects; 231 women (mean age 65.8 ± 8.4; range 35–90 years) and 152 men (mean age 61.5 ± 9.3; range 28–87 years). Four SNPs—G395A in the promoter region, G1110C in exon 2, C1818T and C2298T in exon 4—were genotyped. A significant genotypic and allelic association was observed in SNP C2998T and knee OA, while genotype GA of SNP G395A was significantly associated (__p__ = 0.039) with knee OA in females only. For the first time, an association was observed between SNPs G395A and C2998T of the __KLOTHO__ gene and knee osteoarthritis implicating __KLOTHO__ in OA pathogenesis. © 2008

Who reads Association of KLOTHO gene polymorphisms with knee osteoarthritis in Greek population?

Author

Aspasia Tsezou; Tatsuya Furuichi; Maria Satra; Periklis Makrythanasis; Shiro Ikegawa; Konstantinos N. Malizos

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)

Published

2008

Language

EN

Field

Medicine (Health Sciences)