About this Medicine article
Antiarrhythmic Effects of JTV-519, a Novel Cardioprotective Drug, on Atrial Fibrillation/Flutter in a Canine Sterile Pericarditis Model by Koichiro Kumagai; Hideko Nakashima; Naoki Gondo; Keijiro Saku is a Medicine article available to read on EtoBox.
__Introduction:__ A new cardioprotective drug, JTV‐519, blocks Na^+^ current and inwardly rectifying K^+^ current and inhibits Ca^2+^ current. However, its role in atrial electrophysiology is unknown. We investigated the antiarrhythmic effects of JTV‐519 on atrial fibrillation/flutter in the canine sterile pericarditis model. __Methods and Results:__ In nine dogs with sterile pericarditis, 38 episodes of sustained (>30 sec) atrial fibrillation (8 dogs) and 24 episodes of sustained atrial flutter (7 dogs) were induced by rapid atrial pacing. When atrial fibrillation or atrial flutter was sustained >15 minutes, it was cardioverted and reinduced. The inducibility of atrial fibrillation/flutter, the atrial effective refractory period, and the intra‐atrial conduction time were compared before and after the continuous infusion of JTV‐519 (0.03 mg/kg/min). JTV‐519 significantly decreased the mean number of sustained atrial fibrillation episodes (from 4.2 ± 2.9 to 0 ± 0, P < 0.01). In contrast, atrial flutter was still inducible in 4 dogs after JTV‐519 (from 2.7 ± 2.5 to 1.6 ± 2.1, P = NS). JTV‐519 significantly prolonged effective refractory period (from 123 ± 18 to 143 ± 14 msec, from 12
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- Author
- Koichiro Kumagai; Hideko Nakashima; Naoki Gondo; Keijiro Saku
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Futura Publishing Company, Inc; Blackwell Publishing Inc.; Wiley (ISSN 1540-8167)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)