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Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation by Jian-rong Huang; Ming-hua Zhang; Ying-jie Chen; Yu-ling Sun; Zhi-min Gao; Zhuo-jia Li; Gui-ping Zhang; Yuan Qin; Xiao-yan Dai; Xi-yong Yu; Xiao-qian Wu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation about?
Metabolic cardiomyopathy (MC) is characterized by intracellular lipid accumulation and utilizing fatty acids as a foremost energy source, thereby leading to excess oxidative stress and mitochondrial dysfunction. There is no effective therapy available yet. In this study we investigated whether defective mitophagy contributed to MC and whether urolithin A (UA), a naturally occurring microflora-derived metabolite, could protect against MC in experimental obese mice. Mice were fed high fat diet for 20 weeks to establish a diet-induced obese model. We showed that mitochondrial autophagy or mitophagy was significantly downregulated in the heart of experimental obese mice. UA (50 mg•kg −1 •d −1 , for 4 weeks) markedly activated mitophagy and ameliorated MC in obese mice by gavage. In PA-challenged H9C2 cardiomyocytes, UA (5 μM) significantly increased autophagosomes and decreased autolysosomes. Furthermore, UA administration rescued PINK1/Parkin-dependent mitophagy and relieved mitochondrial defects in the heart of obese mice, which led to improving cardiac diastolic function and ameliorating cardiac remodelling. In PA-challenged primarily isolated cardiomyocytes, both application of mit
Who reads Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jian-rong Huang; Ming-hua Zhang; Ying-jie Chen; Yu-ling Sun; Zhi-min Gao; Zhuo-jia Li; Gui-ping Zhang; Yuan Qin; Xiao-yan Dai; Xi-yong Yu; Xiao-qian Wu
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)