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Inhomogeneous sodium accumulation in the ischemic core in rat focal cerebral ischemia by ^23^Na MRI by Victor E. Yushmanov; Alexander Kharlamov; Boris Yanovski; George LaVerde; Fernando E. Boada; Stephen C. Jones is a Medicine article available to read on EtoBox.
What is Inhomogeneous sodium accumulation in the ischemic core in rat focal cerebral ischemia by ^23^Na MRI about?
## Abstract ## Purpose To test the hypotheses that (i) the regional heterogeneity of brain sodium concentration ([Na^+^]~br~) provides a parameter for ischemic progression not available from apparent diffusion coefficient (ADC) data, and (ii) [Na^+^]~br~ increases more in ischemic cortex than in the caudate putamen (CP) with its lesser collateral circulation after middle cerebral artery occlusion in the rat. ## Materials and Methods ^23^Na twisted projection MRI was performed at 3 Tesla. [Na^+^]~br~ was independently determined by flame photometry. The ischemic core was localized by ADC, by microtubule‐associated protein‐2 immunohistochemistry, and by changes in surface reflectivity. ## Results Within the ischemic core, the ADC ratio relative to the contralateral tissue was homogeneous (0.63 ± 0.07), whereas the rate of [Na^+^]~br~ increase (slope) was heterogeneous (__P__ < 0.005): 22 ± 4%/h in the sites of maximum slope versus 14 ± 1%/h elsewhere (here 100% is [Na^+^]~br~ in the contralateral brain). Maximum slopes in the cortex were higher than in CP (__P__ 0.1). Maximum slope was located at the periphery of ischemic core in 8/10 animals. ## Conclusion Unlike ADC, ^23^Na MRI d
Who reads Inhomogeneous sodium accumulation in the ischemic core in rat focal cerebral ischemia by ^23^Na MRI?
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- Author
- Victor E. Yushmanov; Alexander Kharlamov; Boris Yanovski; George LaVerde; Fernando E. Boada; Stephen C. Jones
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)