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Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging by Zhang, Yonghong ;Ma, Xia ;Chau, Ho-Fai ;Thor, Waygen ;Jiang, Lijun ;Zha, Shuai ;Fok, Wan-Yiu ;Mak, Ho-Nam ;Zhang, Junhui ;Cai, Jing ;Ng, Chi-Fai ;Li, Hongguang ;Parker, David ;Li, Li ;Law, Ga-Lai ;Wong, Ka-Leung is a Materials Science article available to read on EtoBox.

What is Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging about?

We have devised a molecular-to-micellar strategy to incorporate a lanthanide nanoplatform for the delivery of an anticancer drug that simultaneously offers hybrid near-infrared (NIR) and magnetic resonance imaging (MRI) capabilities with defined lanthanide(III) ratio control. This cancer-selective lanthanide-based self-assembled nanocomposite (LnNPs) has been synthesized by conjugating lanthanide-cyclen complexes (cycLn) with a well-known drug-camptothecin (CPT) through a redox-sensitive disulfide bond (-ss-). By accurately controlling the ratio of Gd(III) and Yb(III) complexes, we prepared hybrid nanoparticles (Gd/YbNPs) with both NIR and MR imaging properties. The enhanced stability at ultralow critical aggregation concentrations (CACs), simultaneous optical and MR imaging, improved delivery/chemotherapeutic efficiency, and cancer cell selectivity of such nanomicellar theranostic prodrugs in vitro and in vivo have thus been achieved and validated. The work provides a blueprint combining a stimuli-activated NIR luminescence and real-time MR imaging into a safe and biocompatible nanoplatform for selective cancer treatment.

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Author

Zhang, Yonghong ;Ma, Xia ;Chau, Ho-Fai ;Thor, Waygen ;Jiang, Lijun ;Zha, Shuai ;Fok, Wan-Yiu ;Mak, Ho-Nam ;Zhang, Junhui ;Cai, Jing ;Ng, Chi-Fai ;Li, Hongguang ;Parker, David ;Li, Li ;Law, Ga-Lai ;Wong, Ka-Leung

Publisher

American Chemical Society (ACS)

Published

2021

Language

EN

Field

Materials Science (Physical Sciences)