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Large-scale Association Study on Daily Weight Gain in Pigs Reveals Overlap of Genetic Factors for Growth in Humans by Zexi Cai; Ole Fredslund Christensen; Mogens Sandø Lund; Tage Ostersen; Goutam Sahana is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Large-scale Association Study on Daily Weight Gain in Pigs Reveals Overlap of Genetic Factors for Growth in Humans about?
## Abstract ## Background Imputation from genotyping array to whole-genome sequence variants using resequencing of representative reference populations enhances our ability to map genetic factors affecting complex phenotypes in livestock species. The accumulation of knowledge about gene function in human and laboratory animals can provide substantial advantage for genomic research in livestock species. ## Results In this study, 201,388 pigs from three commercial Danish breeds genotyped with low to medium (8.5k to 70k) SNP arrays were imputed to whole genome sequence variants using a two-step approach. Both imputation steps achieved high accuracies, and in total this yielded 26,447,434 markers on 18 autosomes. The average estimated imputation accuracy of markers with minor allele frequency ≥ 0.05 was 0.94. To overcome the memory consumption of running genome-wide association study (GWAS) for each breed, we performed within-breed subpopulation GWAS then within-breed meta-analysis for average daily weight gain (ADG), followed by a multi-breed meta-analysis of GWAS summary statistics. We identified 15 quantitative trait loci (QTL). Our post-GWAS analysis strategy to prioritize of candi
Who reads Large-scale Association Study on Daily Weight Gain in Pigs Reveals Overlap of Genetic Factors for Growth in Humans?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Zexi Cai; Ole Fredslund Christensen; Mogens Sandø Lund; Tage Ostersen; Goutam Sahana
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)