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Apneic oxygenation reduces the incidence of hypoxemia during emergency intubation: A systematic review and meta-analysis by Ivan Pavlov; Sofia Medrano; Scott Weingart is a Medicine article available to read on EtoBox.

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## Study objective: Apneic oxygenation has been advocated for the prevention of hypoxemia during emergency endotracheal intubation. because of conflicting results from recent trials, the efficacy of apneic oxygenation remains unclear. we performed a systematic review and meta-analysis to investigate the effect of apneic oxygenation on the incidence of clinically significant hypoxemia during emergency endotracheal intubation. ## Methods: Medline, embase, and pubmed databases were searched without language and time restrictions for studies of apneic oxygenation performed in a critical care setting. meta-analysis was conducted with a random-effect model, and according to intention-to-treat allocation wherever applicable. subgroup analyses were performed to ensure the robustness of findings across various clinical outcomes. ## Results: Eight studies (n=1953) were included in the meta-analysis. the pooled absolute risk of clinically significant hypoxemia was 27.6% in the usual care group and 19.1% in the apneic oxygenation group, without any heterogeneity across studies (i=0%; p=0.42). apneic oxygenation reduced the relative risk of hypoxemia by 30% (95% confidence interval 0.59 to 0.82

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Author

Ivan Pavlov; Sofia Medrano; Scott Weingart

Publisher

Elsevier BV

Published

2017

Language

EN

Field

Medicine (Health Sciences)