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Lactate dehydrogenase is an enzyme found in many tissues including the myocardium, kidney, liver, and muscles. It exists as 5 isoenzymes that are tetramers composed of different combinations of H and M subunits with varying affinities for pyruvate and lactate. LD1 and LD2 are increased in conditions like myocardial infarction, megaloblastic anemia, and metastatic liver cancer. The isoenzyme patterns in serum and cerebrospinal fluid can provide diagnostic information for diseases such as bacterial meningitis

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