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An Adverse Outcome Pathway-based Approach to Assess Aurantio-obtusin-induced Hepatotoxicity by Manjiang Hu,Yizhou Zhong,Jun Liu,Shaozhen Zheng,Li Lin,Xi Lin,Boxuan Liang,Yuji Huang,Hongyi Xian,Zhiming Li,Bingli Zhang,Bo Wang,Hao Meng,Jiaxin Du,Rongyi Ye,Zhi Lu,Xifei Yang,Xingfen Yang,Zhenlie Huang is a nonfiction available to read on EtoBox.
What is An Adverse Outcome Pathway-based Approach to Assess Aurantio-obtusin-induced Hepatotoxicity about?
Toxicology, 478 (2022) 153293. doi:10.1016/j.tox.2022.153293 An adverse outcome pathway-based approach to assess aurantio-obtusin-induced hepatotoxicity 1 1 Introduction 2 2 Materials and methods 2 2.1 Chemicals and materials 2 2.2 Cell culture 2 2.3 Cell treatment 2 2.4 Biochemistry 3 2.5 ROS activity detection 3 2.6 mtΔΨ measurement 3 2.7 Determining adenosine triphosphate (ATP) content 3 2.8 Detecting the apoptotic cells 3 2.9 LPO assay 3 2.10 cAMP assay 3 2.11 mRNA expression analysis 3 2.12 Western blot 4 2.13 Statistical analysis 4 3 Results 4 3.1 AO induced hepatotoxicity in the liver cells 4 3.2 AO increased apoptosis in the liver cells via ROS-mediated mitochondrial dysfunction 4 3.3 AO-enhanced LPO contributed to ferroptosis in the liver cells 5 3.4 AO increased ferroptosis in the liver cells via cAMP-PKA-CREB pathway-mediated ACSL4 upregulation 5 3.5 An AOP framework of AO-induced hepatotoxicity 5 3.6 Assessment of confidence in the AOP framework based on tailored Bradford Hill criteria 11 3.6.1 Concordance in dose-response 11 3.6.2 Concordance in temporal relationships among the KEs 12 3.6.3 Concordance in incidence relationships between KEs 12 4 Discussion 12 4.1 AO-in
Who reads An Adverse Outcome Pathway-based Approach to Assess Aurantio-obtusin-induced Hepatotoxicity?
It is typically read by self-directed learners exploring a subject in depth.
Common subject areas: history, science, philosophy, social sciences.
- Author
- Manjiang Hu,Yizhou Zhong,Jun Liu,Shaozhen Zheng,Li Lin,Xi Lin,Boxuan Liang,Yuji Huang,Hongyi Xian,Zhiming Li,Bingli Zhang,Bo Wang,Hao Meng,Jiaxin Du,Rongyi Ye,Zhi Lu,Xifei Yang,Xingfen Yang,Zhenlie Huang
- Publisher
- Elsevier B.V.
- Language
- EN
- Category
- nonfiction
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