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Francisella novicida Two-Component System Response Regulator BfpR Modulates iglC Gene Expression, Antimicrobial Peptide Resistance, and Biofilm Production by Dean, Scott N.; Milton, Morgan E.; Cavanagh, John; van Hoek, Monique L. is a Medicine article available to read on EtoBox.

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Response regulators are a critical part of the two-component system of gene expression regulation in bacteria, transferring a signal from a sensor kinase into DNA binding activity resulting in alteration of gene expression. In this study, we investigated a previously uncharacterized response regulator in __Francisella novicida__, FTN\_1452 that we have named BfpR (Biofilm-regulating __Francisella__ protein Regulator, __FTN\_1452__). In contrast to another Francisella response regulator, QseB/PmrA, BfpR appears to be a negative regulator of biofilm production, and also a positive regulator of antimicrobial peptide resistance in this bacterium. The protein was crystallized and X-ray crystallography studies produced a 1.8 Å structure of the BfpR N-terminal receiver domain revealing interesting insight into its potential interaction with the sensor kinase. Structural analysis of BfpR places it in the OmpR/PhoP family of bacterial response regulators along with WalR and ResD. Proteomic and transcriptomic analyses suggest that BfpR overexpression affects expression of the critical __Francisella__ virulence factor iglC, as well as other proteins in the bacterium. We demonstrate that mutat

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Author

Dean, Scott N.; Milton, Morgan E.; Cavanagh, John; van Hoek, Monique L.

Publisher

Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2011- (ISSN 2235-2988)

Published

2020

Language

EN

Field

Medicine (Health Sciences)