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Effects of the Hyptis martiusii Benth. leaf essential oil and 1,8-cineole (eucalyptol) on the central nervous system of mice by Francisco Rodolpho Sobreira Dantas Nóbrega de Figuêiredo; Álefe Brito Monteiro; Irwin Rose Alencar de Menezes; Valterlúcio dos Santos Sales; Emmily Petícia do Nascimento; Cristina Kelly de Souza Rodrigues; Ana Jaqueline Bitu Primo; Luzia Paulo da Cruz; Érika do Nascimento Amaro; Gyllyandeson de Araújo Delmondes; Juliana Ponciano Leite de Oliveira Sobreira Nóbrega; Maria Janice Pereira Lopes; José Galberto Martins da Costa; Cícero Francisco Bezerra Felipe; Marta Regina Kerntopf is a Medicine article available to read on EtoBox.

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The aim of this study was to characterize the central effects of the Hyptis martiusii leaf essential oil (OEHM) and 1,8-cineole (eucalyptol) using behavioral animal models. Gas chromatography coupled to mass spectrometry (GC/MS) was used to characterize the chemical compounds present in the OEHM. For the behavioral tests, female Swiss mice treated with the OEHM (25, 50, 100 and 200 mg/kg, i.p.) and 1,8-cineole (50 mg/kg, i.p.) were used and subjected to the following tests: open field, elevated cross maze, rotarod, sodium pentobarbital- or ethyl ether-induced sleep time, pentylenetetrazol-induced convulsions, haloperidol-induced catalepsy, and ketamine-induced hyperkinesia. GC/MS analysis identified 20 constituents with the majority of them being monoterpenes and sesquiterpenes, with eucalyptol (1,8-cineol), the major sample compound (25.93%), standing out. The results showed the OEHM (25, 50 100 and 200 mg/kg, i.p.) and its major compound (50 mg/kg, i.p.) reduced animal motility in the open field test, increased pentobarbital- and ethyl ether-induced sleep time, as well as death latency in the pentylenetetrazole-induced convulsion model. However, the tested compounds were devoid o

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Author

Francisco Rodolpho Sobreira Dantas Nóbrega de Figuêiredo; Álefe Brito Monteiro; Irwin Rose Alencar de Menezes; Valterlúcio dos Santos Sales; Emmily Petícia do Nascimento; Cristina Kelly de Souza Rodrigues; Ana Jaqueline Bitu Primo; Luzia Paulo da Cruz; Érika do Nascimento Amaro; Gyllyandeson de Araújo Delmondes; Juliana Ponciano Leite de Oliveira Sobreira Nóbrega; Maria Janice Pereira Lopes; José Galberto Martins da Costa; Cícero Francisco Bezerra Felipe; Marta Regina Kerntopf

Published

2019

Language

EN

Field

Medicine (Life Sciences)