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Zonal Distribution of Allopurinol-oxidizing Enzymes in Rat Liver by Y. Moriwaki; T. Yamamoto; J. Yamakita; S. Takahashi; Z. Tsutsumi; K. Higashino is a Medicine article available to read on EtoBox.

What is Zonal Distribution of Allopurinol-oxidizing Enzymes in Rat Liver about?

Results MPA induces time-and dose-dependent inhibition of proliferation, decrease in GTP pools, arrest at the G1/S interphase and cell death by apoptosis in all cell lines. In LA-N-5 the fraction of apoptotic cells was about 40% at 1 ~M MPA after 48 hours of treatment. Apoptosis was associated with up regulation of p53 and down regulation of Bcl-2 expression. The effects of MPA were, at least partially, reversed by the addition of guanine or guanosine to the culture medium. Conclusion MPA induces apoptosis in human neuroblastoma cell lines, suggesting a potential clinical use of the drug.

Who reads Zonal Distribution of Allopurinol-oxidizing Enzymes in Rat Liver?

Author

Y. Moriwaki; T. Yamamoto; J. Yamakita; S. Takahashi; Z. Tsutsumi; K. Higashino

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-9120)

Published

1997

Language

EN

Field

Medicine (Health Sciences)