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Post-traumatic recovery of muscle soleus in rats is improved via synergistic effect of C60 fullerene and TRPM8 agonist menthol by Dmytro Nozdrenko; Tatiana Matvienko; Oksana Vygovska; Vasil Soroca; Kateryna Bogutska; Alexander Zholos; Peter Scharff; Uwe Ritter; Yuriy Prylutskyy is a Materials Science article available to read on EtoBox.

What is Post-traumatic recovery of muscle soleus in rats is improved via synergistic effect of C60 fullerene and TRPM8 agonist menthol about?

Functional biomechanical parameters of muscle soleus contraction in rats as well as selected blood biochemical parameters were studied during the first 3 days of post-traumatic syndrome progression caused by the destruction of muscle cells by compression. Single administration of the antioxidant C 60 fullerene and the selective agonist of TRPM8 channels menthol were used as therapeutic agents. Injection of C 60 fullerene at a concentration of 1 mg/kg into the damaged muscle improved its contractile function by 25-28%. The use of combined injections of C 60 fullerene and menthol (at the concentration 1 mg/ kg) improved this index by additional 27-39% and simultaneously stabilized the decrease in muscle strength observed throughout the experiment. A tendency towards a decrease in the indexes of the above described biochemical parameters by 10-15% were found with the therapeutic administration of C 60 fullerene. With combined injections of C 60 fullerene and menthol, the above described biochemical parameters decreased by an additional 17-24%. The synergism between the action of menthol and C 60 fullerene on the post-traumatic recovery of skeletal muscle function opens up new perspect

Who reads Post-traumatic recovery of muscle soleus in rats is improved via synergistic effect of C60 fullerene and TRPM8 agonist menthol?

Author

Dmytro Nozdrenko; Tatiana Matvienko; Oksana Vygovska; Vasil Soroca; Kateryna Bogutska; Alexander Zholos; Peter Scharff; Uwe Ritter; Yuriy Prylutskyy

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Materials Science (Physical Sciences)