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Can I read A New Multifunctional Hydroxytyrosol-clofibrate with Hypolipidemic, Antioxidant, and Hepatoprotective Effects on EtoBox?
A New Multifunctional Hydroxytyrosol-clofibrate with Hypolipidemic, Antioxidant, and Hepatoprotective Effects by Xie, Yun-Dong; Chen, Zi-Zhang; Shao, Li-Hua; Wang, Qiu-Tang; Li, Na; Lu, Wen-Fang; Xu, Yan-Hong; Gao, Yu-Qiong; Guo, Li-Ying; Liu, Hao-Le; Li, Yi-Ping; Yang, Guang-De; Bian, Xiao-Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is A New Multifunctional Hydroxytyrosol-clofibrate with Hypolipidemic, Antioxidant, and Hepatoprotective Effects about?
Oxidative stress has been regarded as the leading mechanism of the hepatotoxicity of clofibrate (CF). To achieve multifunctional novel hypolipidemic agents with hypolipidemia, antioxidant, and ameliorating liver injury, clofibric acid derivative hydroxytyrosol-clofibrate (CF-HT) was synthesized by molecular hybridization. CF-HT exhibited significant hypolipidemia, reducing serum triglyceride (TG), total cholesterol (TC), and malonaldehyde (MDA) by 30%, 33%, and 29% in hyperlipidemic mice induced by Triton WR 1339. CF-HT also shown hepatoprotective effect, a significant decrease in hepatic indices toxicity was observed, i.e. aspartate and lactate transaminases (AST and ALT) activities, alkalines phosphatases (ALP), and total bilirubin (TBIL) levels. The liver weight and liver coefficient were also ameliorated. Serum superoxide dismutase (SOD) was significantly elevated, and serum catalase (CAT) and malondialdehyde (MDA) content were remarkably restored. The hepatic glutathione (GSH) content was obviously increased and hepatic oxidized glutathione (GSSG) content was reduced dramatically by CF-HT, as compared to the CF treated mice (p < 0.05). Moreover, the histopathological damage th
Who reads A New Multifunctional Hydroxytyrosol-clofibrate with Hypolipidemic, Antioxidant, and Hepatoprotective Effects?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Xie, Yun-Dong; Chen, Zi-Zhang; Shao, Li-Hua; Wang, Qiu-Tang; Li, Na; Lu, Wen-Fang; Xu, Yan-Hong; Gao, Yu-Qiong; Guo, Li-Ying; Liu, Hao-Le; Li, Yi-Ping; Yang, Guang-De; Bian, Xiao-Li
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2018
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)