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The diagnostic and prognostic relevance of human telomerase reverse transcriptase mRNA expression detected in situ in patients with nonsmall cell lung carcinoma by Yuka Fujita; Toshiaki Fujikane; Satoru Fujiuchi; Yutaka Nishigaki; Yasuhiro Yamazaki; Atsushi Nagase; Tetsuo Shimizu; Yoshinobu Ohsaki; Kenjiro Kikuchi is a Medicine article available to read on EtoBox.
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## Abstract ## BACKGROUND The objectives of this study were to evaluate the diagnostic and prognostic relevance of human telomerase reverse transcriptase (hTERT) detected in situ in patients with nonsmall cell lung carcinoma (NSCLC) and to investigate the possible correlations between hTERT mRNA in NSCLC and the patients' clinicopathologic features, including survival. ## METHODS hTERT mRNA was detected by in situ hybridization in 146 samples from patients with NSCLC. The signal intensity of hTERT mRNA expression was evaluated by two independent observers. The expression level was defined subjectively as strong, moderate, or weak. ## RESULTS hTERT mRNA was detected mainly in the cytoplasm of tumor cells. It was detected in the cytoplasm of 100% of samples from patients with NSCLC but was not detected in normal lung tissue, except in activated lymphocytes. There was a significant correlation between hTERT mRNA expression and pathologic tumor status, pathologic disease stage (pStage), and Ki‐67 labeling index. There was no significant correlation between hTERT mRNA expression and age, gender, pathologic lymph node status (pN), histology, or tumor differentiation. The 5‐year survival
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- Author
- Yuka Fujita; Toshiaki Fujikane; Satoru Fujiuchi; Yutaka Nishigaki; Yasuhiro Yamazaki; Atsushi Nagase; Tetsuo Shimizu; Yoshinobu Ohsaki; Kenjiro Kikuchi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)