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Investigation of Proton Density for Measuring Tissue Temperature by Jing Chen; Bruce L. Daniel; Kim Butts Pauly is a Medicine article available to read on EtoBox.

What is Investigation of Proton Density for Measuring Tissue Temperature about?

## Abstract ## Purpose To examine the temperature dependence of the proton density (PD) in both adipose and muscle tissues, and the application of the PD as a thermometry parameter in breast tissues. ## Materials and Methods Porcine fat samples and bovine muscle samples were successively heated to temperatures ranging from 30°C to 76°C and then cooled. They were then imaged with a dual‐echo spin‐echo sequence. T1 and T2 effects were carefully corrected from the images. The apparent PD (APD) in regions of interest (ROIs) and the sum of the APD in all pixels (Sum\_APD) were measured and analyzed by linear regression. ## Results APD in adipose tissue is linear and reversible, and changes with a 0.3%/°C to 0.45%/°C temperature variation. The temperature coefficient of Sum\_APD in adipose tissue is approximately 0.29%/°C, as predicted from the Boltzmann distribution. However, the results in muscle tissue are more variable. There is an offset in both APD and Sum\_APD between heating and cooling phases, as well as different temperature coefficients between these two phases. ## Conclusion The Sum\_APD in adipose tissue validates the 1/__T__ dependence on temperature. The APD is a potential

Who reads Investigation of Proton Density for Measuring Tissue Temperature?

Author

Jing Chen; Bruce L. Daniel; Kim Butts Pauly

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)

Published

2006

Language

EN

Field

Medicine (Health Sciences)