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Pharmacokinetic Profiling in Drug Research : Biological, Physicochemical, and Computational Strategies by BERNARD TESTA STEFANIE D.KRAMER is a book available to read on EtoBox.

What is Pharmacokinetic Profiling in Drug Research : Biological, Physicochemical, and Computational Strategies about?

<p>Informatics and robotics are the workhorses of a technological revolution in drug research. On them are based combinatorial chemistry, which yields compounds by the many thousands, and high-throughput bioassays, which screen them for activity. The results are avalanches of 'hits', which invade the databases like swarms of locusts. But far from being a plague, these innumerable compounds become a blessing if properly screened for 'drugability', i.e., for 'drug-like' properties such as good pharmacokinetic (PK) behavior. Pharmacokinetic profiling of bioactive compounds has, thus, become a sine qua non condition for cherry-picking the most promising hits. Just as important, but less visible, are the structure-property and structure-ADME relations, which emerge from PK profiling and provide useful feedback when designing new synthetic series. As a result, the screening, design, and optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. To shorten the time-consuming development and high rate of attrition of active compounds ultimately doomed by hidden pharmacokinetic defects, powerful biological, physicochemical, and computational

Author

BERNARD TESTA STEFANIE D.KRAMER

Publisher

Zü̈rich: Verlag Helvetica Chimica Acta ; Weinheim: Wiley-VCH

Published

2006

Language

EN

ISBN

9783906390352

Subjects

Medical, Mathematics, Science