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Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between Azelnidipine and amlodipine on glucose tolerance and endothelial function - a crossover trial (AGENT) by Kosuke Fukao; Kazunori Shimada; Makoto Hiki; Takashi Kiyanagi; Kuniaki Hirose; Atsumi Kume; Hiromichi Ohsaka; Rie Matsumori; Takeshi Kurata; Tetsuro Miyazaki; Hiroyuki Daida is a Medicine article available to read on EtoBox.

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## Background Hypertension is associated with impaired glucose tolerance and insulin resistance. Medical treatment that interferes with various steps in the renin-angiotensin system improves glucose tolerance and insulin resistance. However, it remains unclear if long-acting calcium channel blockers (CCBs) such as azelnidipine and amlodipine affect glucose tolerance and insulin resistance in clinical practice. ## Methods Seventeen non-diabetic patients with essential hypertension who had controlled blood pressure levels using amlodipine (5 mg/day) were enrolled in this study. After randomization, either azelnidipine (16 mg/day) or amlodipine (5 mg/day) was administered in a crossover design for 12-weeks. At baseline and the end of each CCB therapy, samples of blood and urine were collected and 75 g oral glucose tolerance test (OGTT) was performed. In addition, hematopoietic progenitor cells (HPCs) were measured at each point by flow cytometry and endothelial functions were measured by fingertip pulse amplitude tonometry using EndoPAT. ## Results Although blood pressure levels were identical after each CCB treatment, the heart rate significantly decreased after azelnidipine administ

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Author

Kosuke Fukao; Kazunori Shimada; Makoto Hiki; Takashi Kiyanagi; Kuniaki Hirose; Atsumi Kume; Hiromichi Ohsaka; Rie Matsumori; Takeshi Kurata; Tetsuro Miyazaki; Hiroyuki Daida

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2002-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1475-2840)

Published

2011

Language

EN

Field

Medicine (Health Sciences)