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Seizure Pathways Change on Circadian and Slower Timescales in Individual Patients with Focal Epilepsy by Schroeder, Gabrielle M.; Diehl, Beate; Chowdhury, Fahmida A.; Duncan, John S.; de Tisi, Jane; Trevelyan, Andrew J.; Forsyth, Rob; Jackson, Andrew; Taylor, Peter N.; Wang, Yujiang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Seizure Pathways Change on Circadian and Slower Timescales in Individual Patients with Focal Epilepsy about?

## Significance Epilepsy is an episodic disease characterized by brief periods of abnormal brain activity, known as seizures, that often have clinical correlates. In many patients, seizures preferentially happen during certain stages of daily and multiday cycles. However, it is unclear whether and how seizures themselves change over time, even though such variability may have clinical implications. To address this knowledge gap, we quantitatively analyze the nature of within-patient variability in seizure network evolutions. Contrary to common expectations, we find seizure variability throughout our cohort. Moreover, we demonstrate that seizures do not change randomly; instead, they also appear to fluctuate over daily and slower timescales. Ultimately, we may improve treatments by tailoring interventions to the full repertoire of seizures in each patient.

Who reads Seizure Pathways Change on Circadian and Slower Timescales in Individual Patients with Focal Epilepsy?

Author

Schroeder, Gabrielle M.; Diehl, Beate; Chowdhury, Fahmida A.; Duncan, John S.; de Tisi, Jane; Trevelyan, Andrew J.; Forsyth, Rob; Jackson, Andrew; Taylor, Peter N.; Wang, Yujiang

Publisher

National Academy of Sciences; Proceedings of the National Academy of Sciences; Oxford University Press (OUP); Publons; ScienceOpen (ISSN 0027-8424)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)