Opening book details…
Can I read Potential anti-acanthamoebic effects through inhibition of CYP51 by novel quinazolinones on EtoBox?
Potential anti-acanthamoebic effects through inhibition of CYP51 by novel quinazolinones by Usman Ahmed; Keat-Yie Ho; Samson Eugin Simon; Syed Muhammad Saad; Seng-Kai Ong; Areeba Anwar; Kuan Onn Tan; Nanthini Sridewi; Khalid Mohammed Khan; Naveed Ahmed Khan; Ayaz Anwar is a Medicine article available to read on EtoBox.
What is Potential anti-acanthamoebic effects through inhibition of CYP51 by novel quinazolinones about?
Acanthamoeba spp. are free living amoebae which can give rise to Acanthamoeba keratitis and granulomatous amoebic encephalitis. The surface of Acanthamoeba contains ergosterol which is an important target for drug development against eukaryotic microorganisms. A library of ten functionally diverse quinazolinone derivatives (Q1–Q10) were synthesised to assess their activity against Acanthamoeba castellanii T4. The in-vitro effectiveness of these quinazolinones were investigated against Acanthamoeba castellanii by amoebicidal, excystation, host cell cytopathogenicity, and NADPH-cytochrome c reductase assays. Furthermore, wound healing capability was assessed at different time durations. Maximum inhibition at 50 μg/mL was recorded for compounds Q5, Q6 and Q8, while the compound Q3 did not exhibit amoebicidal effects at tested concentrations. Moreover, LDH assay was conducted to assess the cytotoxicity of quinazolinones against HaCaT cell line. The results of wound healing assay revealed that all compounds are not cytotoxic and are likely to promote wound healing at 10 μg/mL. The excystation assays revealed that these compounds significantly inhibit the morphological transformation of
Who reads Potential anti-acanthamoebic effects through inhibition of CYP51 by novel quinazolinones?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Usman Ahmed; Keat-Yie Ho; Samson Eugin Simon; Syed Muhammad Saad; Seng-Kai Ong; Areeba Anwar; Kuan Onn Tan; Nanthini Sridewi; Khalid Mohammed Khan; Naveed Ahmed Khan; Ayaz Anwar
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)