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Can I read Biomechanical and Ultrastructural Comparison of Cryopreservation and a Novel Cellular Extraction of Porcine Aortic Valve Leaflets on EtoBox?
Biomechanical and Ultrastructural Comparison of Cryopreservation and a Novel Cellular Extraction of Porcine Aortic Valve Leaflets by David W. Courtman; Christopher A. Pereira; Sue Omar; Shari E. Langdon; J. Michael Lee; Gregory J. Wilson is a Medicine article available to read on EtoBox.
What is Biomechanical and Ultrastructural Comparison of Cryopreservation and a Novel Cellular Extraction of Porcine Aortic Valve Leaflets about?
Heart valve substitutes of biological origin often fail by degenerative mechanisms. Many authors have hypothesized that mechanical fatigue and structural degradation are instrumental to in vivo failure. Since the properties of the structural matrix at implantation may predetermine failure, we have examined the ultrastructure, fracture, mechanics, and uniaxial high-strain-rate viscoelastic properties of (1) fresh, (2) cryopreserved, and (3) cellular extracted porcine aortic valve leaflets. The cellular extraction process is being developed in order to reduce immunological attack and calcification. Cryopreservation causes cellular disruption and necrotic changes throughout the tissue, whereas extraction removes all cells and lipid membranes. Both processes leave an intact collagen and elastin structural matrix and preserve the high-strain-rate viscoelastic characteristics of the fresh leaflets. Extraction does cause a 20% reduction in the fracture tension and increases tissue extensibility, with the percent strain at fracture rising to 45.3 +-4 (mean ? SEM) from 31.5 ? 3 for fresh leaflets. However, extraction does preserve matrix structure and mechanics over the physiological loadin
Who reads Biomechanical and Ultrastructural Comparison of Cryopreservation and a Novel Cellular Extraction of Porcine Aortic Valve Leaflets?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- David W. Courtman; Christopher A. Pereira; Sue Omar; Shari E. Langdon; J. Michael Lee; Gregory J. Wilson
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)
- Published
- 1995
- Language
- EN
- Field
- Medicine (Health Sciences)