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Differential and long‐lasting alterations of high‐voltage activated calcium currents in CA1 and dentate granule neurons after status epilepticus by Jan A. Gorter; Aren J. Borgdorff; Erwin A. Van Vliet; Fernando H. Lopes Da Silva; Wytse J. Wadman is a Neuroscience article available to read on EtoBox.

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## Abstract The effects on high‐voltage activated (HVA) calcium currents were examined in hippocampal CA1 cells and dentate gyrus (DG) granule neurons, 2 days (short‐term; ST) and 2–3 months (long‐term; LT) after electrically induced, limbic electrographic and behavioural seizures in rats. Whole‐cell voltage‐clamp recordings in dissociated CA1 neurons of LT rats showed a decrease in the sustained HVA calcium current amplitude and a faster inactivation of the current both in rats that had experienced a status epilepticus (post‐SE rats) and those in which the stimulation did not lead to SE (non‐SE rats). In CA1 neurons of LT–SE rats this resulted in a reduced Ca^2+^ entry through the HVA channels. Perforated‐patch voltage‐clamp recordings in dissociated DG granule neurons of LT–SE rats showed an increased sustained HVA current amplitude compared to controls and non‐SE rats, leading to an increased Ca^2+^ entry via HVA calcium channels. Two days after SE, we observed an increased Ca^2+^ entry for a defined depolarization, although the change in HVA current amplitude and inactivation rate did not reach significance. We also observed a decrease in calbindin‐D~28k~ staining in DG post‐SE

Who reads Differential and long‐lasting alterations of high‐voltage activated calcium currents in CA1 and dentate granule neurons after status epilepticus?

Author

Jan A. Gorter; Aren J. Borgdorff; Erwin A. Van Vliet; Fernando H. Lopes Da Silva; Wytse J. Wadman

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

2002

Language

EN

Field

Neuroscience (Life Sciences)