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Does vascular endothelial dysfunction play a role in physical frailty and sarcopenia? A systematic review by Amarasekera, Anjalee Thanuja; Chang, Dennis; Schwarz, Peter; Tan, Timothy C is a Medicine article available to read on EtoBox.

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## Abstract ## Background Frailty is strongly associated with adverse cardiovascular outcomes; however, the underlying pathophysiological processes are largely unknown. Vascular endothelial dysfunction (VED) is the earliest stage of cardiovascular disease (CVD) progression and predicts long-term CVD outcomes. Both these conditions share an elevated inflammatory state as a common pathological factor. ## Objective Systematic literature review was conducted to examine the evidence supporting an association between VED and physical frailty and/or sarcopenia, in electronic databases including Scopus, Ovid Medline, CINAHL, ScienceDirect, ProQuest Health & Medicine and Embase from January 1980 to August 2019. ## Results A total of 18 studies met the inclusion criteria. VED is independently associated with increased frailty phenotypes and measures of sarcopenia. Several markers of VED, including higher levels of asymmetric dimethylarginine, abnormal ankle brachial index, pulse wave velocity, pulse pressure and lower levels of flow-mediated dilatation, peripheral blood flow and endothelial progenitor cell counts, have been associated with frailty/sarcopenia measurements. Some studies demons

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Author

Amarasekera, Anjalee Thanuja; Chang, Dennis; Schwarz, Peter; Tan, Timothy C

Publisher

Oxford University Press; Oxford University Press (OUP) (ISSN 0002-0729)

Published

2021

Language

EN

Field

Medicine (Health Sciences)