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Granulomatosis with Polyangiitis (GPA), formerly Wegener granulomatosis, is a severe form of necrotizing vasculitis affecting small- to medium-sized blood vessels, primarily in the respiratory tracts and kidneys. It is characterized by T-cell-mediated hypersensitivity, granuloma formation, and the presence of PR3-ANCAs as diagnostic markers. Early diagnosis and aggressive immunosuppressive treatment are crucial for improving patient outcomes, as untreated GPA has a high mortality rate.

Author

am0595725079

Language

EN