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Stimulation of L-type Ca2+ channel in growth cones activates two independent signaling pathways by Katsumi Ohbayashi; Haruhiko Fukura; Hiroshi K. Inoue; Yoshiaki Komiya; Michihiro Igarashi is a Neuroscience article available to read on EtoBox.
What is Stimulation of L-type Ca2+ channel in growth cones activates two independent signaling pathways about?
Although growth cones respond to various modulators of neurite outgrowth, such as neurotrophins, neurotransmitters, and cell adhesion molecules, the signal-transducing mechanisms for these modulators in growth cones are unclear. Since recent studies have suggested that the signals of these modulators are mediated by Ca2+ influx through L-type voltage-sensitive Ca2+ channels (VSCCs) in the growth cone, we examined L-type VSCC-dependent signaling pathways, using isolated growth cones (IGCs) from developing rat forebrains. Binding assays revealed that L-type VSCC is enriched in growth cone membrane and gradually decreased in amount developmentally, while N-type VSCC has the opposite tendency. In intact IGCs, Bay K 8644 (BK, an L-type agonist) induced much more rapid elevation of [Ca2+]i than that in adult synaptosomes. Ca2+-dependent phosphorylation of GAP-43 and MARCKS protein by protein kinase C (PKC) was enhanced in the IGC by BK, resulting in the release of these proteins from the membrane, which is consistent with our recent report. In addition, the Ca2+-dependent degradation of brain spectrin (fodrin) by calpain was also enhanced by BK or GABA, consequently inducing the release
Who reads Stimulation of L-type Ca2+ channel in growth cones activates two independent signaling pathways?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Katsumi Ohbayashi; Haruhiko Fukura; Hiroshi K. Inoue; Yoshiaki Komiya; Michihiro Igarashi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 1998
- Language
- EN
- Field
- Neuroscience (Life Sciences)