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Genome‐Wide Association Study of Lean Nonalcoholic Fatty Liver Disease Suggests Human Leukocyte Antigen as a Novel Candidate Locus by Yoshida, Ken ;Yokota, Kazuha ;Kutsuwada, Yukinobu ;Nakayama, Kazuhiro ;Watanabe, Kazuhisa ;Matsumoto, Ayumi ;Miyashita, Hiroshi ;Khor, Seik‐soon ;Tokunaga, Katsushi ;Kawai, Yosuke ;Nagasaki, Masao ;Iwamoto, Sadahiko is a Medicine article available to read on EtoBox.

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Nonalcoholic fatty liver disease (NAFLD) is supposed to manifest its metabolic phenotype in the liver, but it is common to have lean individuals diagnosed with NAFLD, known as lean NAFLD. We conducted a two‐stage analysis to identify NAFLD‐associated loci in Japanese patients. In stage I, 275 metabolically healthy normal‐weight patients with NAFLD were compared with 1,411 non‐NAFLD controls adjusted for age, sex, and alcohol consumption by a genome‐wide association study (GWAS). In stage II, human leukocyte antigen (__HLA__) in chromosome 6 (chr6) (__P__ = 6.73E‐08), microRNA (MIR) __MIR548F3__ in chr7 (__P__ = 4.25E‐07), myosin light chain 2 (__MYL2__) in chr12 (__P__ = 4.39E‐07), and glycoprotein precursor (__GPC__)__6__ in chr13 (__P__ = 5.43E‐07), as suggested by the GWAS, were assessed by single nucleotide polymorphism (SNP) association analysis of whole NAFLD against non‐NAFLD in 9,726 members of the general population. A minor allele of the secondary lead SNP in chr6, rs2076529, was significantly associated (odds ratio [OR], 1.19; 95% confidence interval [CI], 1.11‐1.28; __P__ = 2.10E‐06) and the lead SNP in chr7 was weakly associated (OR 1.15; 95% CI, 1.04‐1.27; __P__ = 6.1

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Author

Yoshida, Ken ;Yokota, Kazuha ;Kutsuwada, Yukinobu ;Nakayama, Kazuhiro ;Watanabe, Kazuhisa ;Matsumoto, Ayumi ;Miyashita, Hiroshi ;Khor, Seik‐soon ;Tokunaga, Katsushi ;Kawai, Yosuke ;Nagasaki, Masao ;Iwamoto, Sadahiko

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2020

Language

EN

Field

Medicine (Health Sciences)