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Reply: Outcome of recurrent hepatitis C virus after liver transplantation in a randomized trial of tacrolimus monotherapy versus triple therapy: Letters to the Editors by Dinesh Jothimani; Timothy J. S. Cross is a Medicine article available to read on EtoBox.
What is Reply: Outcome of recurrent hepatitis C virus after liver transplantation in a randomized trial of tacrolimus monotherapy versus triple therapy: Letters to the Editors about?
We read with interest the article by Manousou and colleagues, 1 investigating the impact of tacrolimus monotherapy (MT) versus triple therapy (TT) on recurrent hepatitis C infection after liver transplantation. This study examined hepatic fibrosis progression in patients randomized to tacrolimus MT versus corticosteroid, tacrolimus, and azathioprine TT. Seventeen of 54 patients (31.4%) in the MT group and 10 of 49 patients (20.4%) in the TT group reached Ishak stage 4 (S4) over a median of 26 and 39 months, respectively. In multivariate analysis, randomization to MT (odds ratio 1⁄4 0.7, 95% confidence interval 1⁄4 0.066-0.847) and a diagnosis of acute hepatitis (odds ratio 1⁄4 3.59, 95% confidence interval 1⁄4 1.108-9.823) were associated with S4. Acute hepatitis was more common in the MT group (17/54) than in the TT group (8/49) over a median of 4.4 and 4.8 months, respectively. The authors concluded that TT prolongs graft survival. This may be an overinterpretation because the authors failed to demonstrate statistically significant differences in mortality (16.7% MT versus 12.2% TT) or retransplantation rates (9.6% with MT versus 7.8% with TT) between the groups. TT appeared to d
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- Author
- Dinesh Jothimani; Timothy J. S. Cross
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)