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Can I read Synthesis, Absolute Configuration and Pharmacological Evaluation of Tiaprofenic Acid Antipodes on EtoBox?
Synthesis, Absolute Configuration and Pharmacological Evaluation of Tiaprofenic Acid Antipodes by S Droux; G Gigliotti; P Joly; F Perrier; V Vincent; PA Robson; RA Williamson; F Petit is a Chemistry article available to read on EtoBox.
What is Synthesis, Absolute Configuration and Pharmacological Evaluation of Tiaprofenic Acid Antipodes about?
Dextrorotatory and levorotatory antipodes (RU 10518. RU 40519) of the non-steroidal antiinflammatory drug (NSAID) racemic tiaprofenic acid (RU 15060) have been prepared by means of a new patented stereoconversion process. Unlike other arylpropionic acids, their absolute configurations. determined by circular dichroism, were R for the dextrorotatory enantiomer and S for the levorotatory enantiomer. Pharmacological evaluation showed that R-(+)-RU 40.5 I8 displays a potent in vitro inhibition of guinea-pig polymorphonuclear leukocytes (PMNL) cyclooxygenase and in vivo a better analgesic activity than its racemate or S-(-)-RU 405 19 on the writhing test in the rat. Racemate and enantiomers showed similar antiinflammatory activity in carrageenaninduced paw oedema in the rat. These tindings indicate that unlike other NSAIDs, the dextrorotatory enantiomer R is the active antipode for tiaprofenic acid. antipode / stereoconversion / inflammation / analgesia I cyclooxygenase
Who reads Synthesis, Absolute Configuration and Pharmacological Evaluation of Tiaprofenic Acid Antipodes?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- S Droux; G Gigliotti; P Joly; F Perrier; V Vincent; PA Robson; RA Williamson; F Petit
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)
- Published
- 1997
- Language
- EN
- Field
- Chemistry (Physical Sciences)