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Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects by Cyril Berthet; Fabienne Guéhenneux; Valérie Revol; Christiane Samarut; Agnès Lukaszewicz; Colette Dehay; Charles Dumontet; Jean-Pierre Magaud; Jean-Pierre Rouault is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects about?
## Abstract **Background:** Several recent reports have connected protein methylation with differentiation. Furthermore, the BTG/TOB proteins have also been implicated in such control. BTG1 and 2 have been shown to interact with PRMT1 (predominant cellular arginine N‐methyltransferase of type I). **Results:** First, we have studied the interaction between PRMT1 and the proteins of the BTG/TOB family. We show that boxC, a sequence present only in BTG1 and BTG2, is essential for this association. Using boxC peptide, we have investigated the importance of PRMT1/BTG protein association during type I protein methylation reactions. Finally, we show that the addition of boxC fused to penetratin interferes with the neuronal differentiation of PC12 cells and ES cell‐derived neurones. **Conclusions:** Taken together, these results indicate that PRMT1/BTG proteins could play a key role in the arginine methylation‐mediated signalling pathway as well as in neuronal differentiation.
Who reads Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Cyril Berthet; Fabienne Guéhenneux; Valérie Revol; Christiane Samarut; Agnès Lukaszewicz; Colette Dehay; Charles Dumontet; Jean-Pierre Magaud; Jean-Pierre Rouault
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1356-9597)
- Published
- 2002
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)