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Adhesion Receptors of Intimal and Subintimal Cells of the Normal Synovial Membrane by A. Demaziere; N. A. Athanasou is a Medicine article available to read on EtoBox.

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## Abstract The distribution of cell adhesion molecules (CAMs) and matrix proteins in the normal synovium of four subjects was studied by immunohistology in order to determine the factors governing the cellular and tissue organization of the intimal and subintimal compartments. Basement membrane proteins, laminin, and collagen type IV, as well as vitronectin and fibronectin, were identified in the intima and there was corresponding expression of integrin and non‐integrin receptors (e.g., CD29, CD49b, CD49d, CD49e, CD49f, CD51, CD61, CD44) for these matrix proteins. There were notable differences in CAM expression between intimal, subintimal, and vascular compartments of the synovial membrane. Phenotypic heterogeneity for CAMs involved in cell–cell interactions, particularly CDlla, CD 11 b, ICAM‐1, and HLA‐DR, was also present. The range of CAMs expressed by synovial and endothelial cells not only indicates a structural role for these antigens, but also suggests that they may control leucocyie traffic into the membrane, including recruitment of cells into the synovial lining.

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Author

A. Demaziere; N. A. Athanasou

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

1992

Language

EN

Field

Medicine (Health Sciences)